GPCR modulator-1
CAS No. : 1407592-99-7
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| Cat. No. : | HY-124803 |
| M.Wt: | 515.53 |
| Formula: | C26H28F3N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GPCR modulator-1 is a negative allosteric modulator of the GLP-1 receptor (GLP-1R). GPCR modulator-1 can be used for the study of type 2 diabetes[1]. In Vitro:GPCR modulator-1 (PF-06372222) can effectively inhibit the cAMP accumulation caused by GLP-1 stimulation in HEK-293T cells expressing wild-type GLP-1R. Its pIC50 value is 5.15. After mutations at C347 and I328, its efficacy is enhanced, with pIC50 values of 5.97 and 5.55, respectively[1].
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