CAN508
CAS No. : 140651-18-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $128 | In-stock |
| 25mg | $256 | In-stock |
| 50mg | $385 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-100429 |
| M.Wt: | 218.22 |
| Formula: | C9H10N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. Antitumor activity[1][2].
In Vitro: CAN508 reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays[1].
CAN508 (20-40 μM; 72 hours) significantly reduces cell proliferation in a dose dependent manner in all three esophageal adenocarcinoma cell lines (SKGT4, OE33 and FLO-1 cells) with IC50s ranging from 34.99 to 91.09 μM[2].
CAN508 (40 μM; 72 hours) increases apoptosis in all three esophageal adenocarcinoma cells[2].
In Vivo: CAN508 (60 mg/kg; i.p.; daily for 10 days) has antitumor effects in esophageal adenocarcinoma xenografts[1].
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