Capreomycin (sulfate)
CAS No. : 1405-37-4
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|---|---|---|
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| Cat. No. : | HY-17566 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 37 mg/mL |
Capreomycin sulfate is a macrocyclic peptide antibiotic that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease[1][2][3][4][5].
In Vitro: Capreomycin sulfate (10-200 μM; 80 h) inhibits the formation of insulin fibrils in human erythrocytes in a concentration-dependent manner (IC50=69.98 μM) and has a delayed fibrillation process[3]. Capreomycin sulfate (75-100 μM; 60 min) shows a dose-dependent protective effect against amyloid fibril-induced erythrocyte damage and hemolysis[3]. Capreomycin sulfate (100 μM; 0-48 h) effectively destroys fibrils in erythrocytes in a time-dependent manner[3].
In Vivo: Capreomycin sulfate (1.4-14.5 mg/kg for insufflation; 20 mg/kg for i.m., 4 weeks) decreases the wet lung weight and lowers bacterial burden in the lungs of infected guinea pigs[2].
Pharmacokinetic Analysis in the guinea pig model[2]
| Route | Dose (mg/kg) | AUC0-t (ng h/mL) | CL_F (mL/h kg) | K (h-1) | t1/2 (h) | MRT (h) | Cmax (ng/mL) | Tmax (h) | MAT (h) | F0-t |
| i.v. | 20 | 49.29 | 0.42 | 0.92 | 0.75 | 0.88 | 53.36 | 0.08 | / | 1.00 |
| i.m. | 20 | 58.2 | 0.35 | 0.68 | 1.09 | 1.44 | 32.33 | 0.36 | 0.44 | 1.20 |
| Insufflation | 14.5 | 16.95 | 0.54 | 0.48 | 1.53 | 1.80 | 6.70 | 0.31 | 0.80 | 0.54 |
| Insufflation | 7.2 | 8.2 | 0.52 | 0.45 | 1.68 | 1.72 | 3.34 | 0.38 | 0.72 | 0.59 |
| Insufflation | 1.4 | 1.15 | 0.67 | 0.71 | 1.22 | 1.01 | 0.92 | 0.5 | / | 0.41 |