BF844
CAS No. : 1404506-35-9
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| Cat. No. : | HY-120726 |
| M.Wt: | 378.85 |
| Formula: | C21H19ClN4O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1)N48K. BF844 induces CLRN1N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo[1].
In Vitro: BF844 (compound 3) (0.846 µM) effectively inhibits HSP60 activity (87.07±27.70% inhibition) and moderately inhibited HSP90 (40.06±19.10% inhibition)[1].
BF844 (2.90 µM; 24 h) induces about 6% of total CLRN1N48K to be transported to the plasma membrane in C1, D1, D6 cells[1].
BF844 (2.90 µM; 24 h) effectively increases the amount of non-glycosylated CLRN1 and non-glycosylated CLRN1 is effectively transported to the plasma membrane in C1 and D1 cells[1].
In Vivo: BF844 shows good penetration into the retina and cochlea in vivo[1].
BF844 (10 mg/kg; i.p.) shows significantly preserves hearing in Tg;KI/KI mice[1].
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