Vancomycin


CAS No. : 1404-90-6

1404-90-6
Price and Availability of CAS No. : 1404-90-6
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25mg $50 In-stock
50mg $80 In-stock
100mg $120 In-stock
1g $360 In-stock
5g $720 In-stock
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Cat. No. : HY-B0671
M.Wt: 1449.25
Formula: C66H75Cl2N9O24
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 1404-90-6 :

Vancomycin is an antibiotic for the treatment of bacterial infections. Vancomycin acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis. In Vitro:Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2]. In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Vancomycin can be used to induce renal injury models[4].

Induction of Kidney Injury Model[4]
Background
Vancomycin induces oxidative stress-related apoptosis in animals.
Specific Modeling Methods
Mice: C57BL/6 • male • 6-week-old
Administration: 400 mg/kg • ip • once daily for 7 weeks
Modeling Indicators
Molecular changes: Induced cell apoptosis and increase in kidney Cr, BUN, MDA, IL-1β, IL-6, TNF-α, and NF-κB.

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