XIAP/cIAP1 antagonist-1
CAS No. : 1403898-55-4
| Size | Price | Stock |
|---|---|---|
| 100 mg | Get quote | |
| 250 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-102051 |
| M.Wt: | 509.66 |
| Formula: | C29H40FN5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
XIAP/cIAP1 antagonist-1 is a potent and orally active XIAP/cIAP1 antagonist with EC50s of 5.1 nM and 0.32 nM for XIAP and cIAP1, respectively. XIAP/cIAP1 antagonist-1 inhibits the tumor growth in dose-dependent manner in vivo[1].
In Vitro: XIAP/cIAP1 antagonist-1 (compound 26) shows antiproliferation activity in MDA-MB-231 cells witn an IC50 value of 4.4 nM[1].
In Vivo: XIAP/cIAP1 antagonist-1 (compound 26) (7.5, 15, 30 mg/kg; p.o.; daily for 24 days) inhibits the tumor growth in dose-dependent manner[1].
XIAP/cIAP1 antagonist-1 (1 mg/kg for i.v.; 5, 30 mg/kg for p.o.) shows oral bioavailability (F=22%) at 5 mg/kg[1].
Pharmacokinetic Parameters of XIAP/cIAP1 antagonist-1 in Balb/c SCID mice[1].
| dose (mg/kg) | route | Tmax (h) | Cmax (µg/mL) | CLp (mL/min/kg) | Vss (L/kg) | half life (h) | AUC (µg·h/mL) | F (%) |
| 1 | IV | 40.9 | 6.4 | 3.0 | 0.41 | |||
| 5 | PO | 2 | 0.12 | 1.8 | 0.45 | 22 | ||
| 30 | PO | 1 | 1.7 | 12.1 |
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- XIAP/cIAP1 antagonist-1
- Cat. No.:
- HY-102051
- Quantity:
Your information is safe with us.