Nexturastat A
CAS No. : 1403783-31-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $119 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $255 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $605 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16699 |
| M.Wt: | 341.40 |
| Formula: | C19H23N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 56 mg/mL |
Nexturastat A is a potent, selective HDAC6 inhibitor. Nexturastat A has inhibitory for HDAC6 with an IC50 of 5 nM. Nexturastat A can be used for the research of multiple myeloma (MM)[1][2].
IC50 & Target:IC50: 5 nM (HDAC6)[1]
In Vitro:Nexturastat A (5 g) has inhibitory for HDAC6 with IC50 values of 0.005 μM[1].
Nexturastat A (0-10 μM; 24 h) has substrate selectivity for HDAC62[1].
Nexturastat A has antiproliferative activity against B16 murine melanoma cells with IC50 values of 14.3 μM[1].
Nexturastat A (NexA) (0-40 μM; 48 h) suppresses viability and induced G1 phase arrest of human MM cells[2].
Nexturastat A (0, 30, 40 μM; 48 h) promotes apoptosis of MM cells via transcriptional activation of the p21 promoter[2].
In Vivo:Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM[2].
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