Amoxapine
CAS No. : 14028-44-5
(Synonyms: CL-67772)
| Size | Price | Stock |
|---|---|---|
| 250mg | $60 | In-stock |
| 500mg | $78 | In-stock |
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| Cat. No. : | HY-B0991 |
| M.Wt: | 313.79 |
| Formula: | C17H16ClN3O |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic) |
Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death[1][2][3].
IC50 & Target:5-HT Receptor and Serotonin Transporter[3]
In Vitro:Amoxapine (10 μM; 3-48 h) reduces the cytotoxicity induced by mycobacterium bovis (BCG) and inhibits the survival of BCG in macrophages. The minimum inhibitory concentration (MIC90) for BCG is 53 μM[1].
Amoxapine (10 μM; 24 h) induces autophagy in mycobacteria-infected macrophages in a mTOR-dependent manner[1].
In Vivo:Amoxapine (3-5 mg/kg; Oral administration; 2 weeks) enhances host defense against M. tuberculosis (Mtb) in mouse models[1].
Amoxapine (10 mg/kg; Intraperitoneal injection; 28 days) can affect the electrophysiology of rat atrial[2].
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