hSMG-1 inhibitor 11j
CAS No. : 1402452-15-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1400 | In-stock |
| 50mg | $2000 | In-stock |
| 100mg | $3000 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-124719 |
| M.Wt: | 566.07 |
| Formula: | C27H28ClN7O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 80 mg/mL (ultrasonic) |
hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].
In Vitro: hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells[1].
hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC50 of 75 nM[1].
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