Palladium(Ⅱ) acetylacetonate
CAS No. : 14024-61-4
(Synonyms: Palladium(Ⅱ) 2,4-pentanedionate; Pd(acac)2)
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| 5g | $293 | In-stock |
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| Cat. No. : | HY-W020952 |
| M.Wt: | 304.62 |
| Formula: | C10H14O4Pd |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
Palladium(II) acetylacetonate is a metal-organic complex. Palladium(II) acetylacetonate upregulates the expression of GRP78, ATF-4, XBP-1, CHOP, and phosphorylated c-Jun. Palladium(II) acetylacetonate induces Apoptosis. Palladium(II) acetylacetonate has anticancer effects against non-small cell lung cancer, gastric cancer, leukemia, and cervical cancer[1][2][3].
In Vitro:Palladium(Ⅱ) acetylacetonate (72 h) shows stronger cytotoxicity than Cisplatin (HY-17394) in H460, BGC-823, HL-60, and Hela cells (IC50 values in H460 cells: 4.56 μM (Palladium(Ⅱ) acetylacetonate) vs. 10.17 μM (Cisplatin))[2].
Palladium(Ⅱ) acetylacetonate (5-20 μM; 16 h) induces apoptosis in H460 cells in a dose-dependent manner[2].
In Vivo:Palladium(Ⅱ) acetylacetonate (1-2 mg/kg; i.p.; every 2 days; 16 days) significantly inhibits the growth of H460 tumor xenografts in athymic BALB/cA nu/nu female mice [2].
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