ASP9436


CAS No. : 1401807-89-3

1401807-89-3
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Cat. No. : HY-120291
M.Wt: 498.40
Formula: C25H25Cl2N5O2
Purity: >98 %
Solubility:
Introduction of 1401807-89-3 :

ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia[1]. In Vivo:ASP9436 (Compound 38 b) (0.001-30 mg/kg, p.o., single administration) attenuates locomotor activity and ameliorates visual recognition memory impairment in neonatal mice in the phencyclidine (PCP)-induced hyperlocomotion mouse model[1].

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