MRT00033659
CAS No. : 1401731-54-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $135 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $366 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $880 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117857 |
| M.Wt: | 266.30 |
| Formula: | C15H14N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1].
In Vitro: MRT00033659 (5-40 µM; 48 hours) is sufficient to significantly reduce cell number of 5 µM[1].
MRT00033659 (1-80 µM; 48 hours) induces substantial cell death from 5 µM[1].
MRT00033659 (0.2-80 µM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2 and p21 proteins, as well as E2F-1 destabilisation from 0.2 µM to 5 µM[1].
MRT00033659 does not inhibit p38α MAPK[1].
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