Ibiglustat


CAS No. : 1401090-53-6

(Synonyms: Venglustat; SAR402671; GZ402671)

1401090-53-6
Price and Availability of CAS No. : 1401090-53-6
Size Price Stock
2mg $50 In-stock
5mg $95 In-stock
10mg $175 In-stock
25mg $310 In-stock
50mg $450 In-stock
100mg $630 In-stock
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Cat. No. : HY-16743
M.Wt: 389.49
Formula: C20H24FN3O2S
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 1401090-53-6 :

Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease[1][2]. IC50 & Target: Glucosylceramide synthase[1]. In Vitro: Ibiglustat (SAR402671) (1 μM, 15 days; Fabry disease (FD) cells) is close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes[4]

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