PACMA 31
CAS No. : 1401089-31-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $105 | In-stock |
| 25mg | $210 | In-stock |
| 50mg | $352 | In-stock |
| 100mg | $585 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100433 |
| M.Wt: | 430.47 |
| Formula: | C21H22N2O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1]. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IC50 & Target:IC50: 10 μM (protein disulfide isomerase)[1] In Vitro: PACMA 31 (0-10 μM; 24 hours) significantly inhibits colony formation in OVCAR-8 cells in a dose-dependent manner[1]. In Vivo: PACMA 31 (20-200 mg/kg; i.p.; daily for 62 days) suppresses tumor growth in human ovarian cancer mouse xenografts [1].
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