CCT251455
CAS No. : 1400284-80-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1800 | In-stock |
| 50mg | $3000 | In-stock |
| 100mg | $4600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12603 |
| M.Wt: | 503.98 |
| Formula: | C26H26ClN7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM. IC50 & Target: IC50: 3 nM (MPS1)[1] In Vitro: CCT251455 is a highly potent inhibitor of MPS1 that demonstrates high selectivity versus kinases tested in a broad kinome profiling panel. CCT251455 inhibits P-MPS1 with an IC50 of 0.04 μM in cell-based assay and has a GI50 of 0.16 μM[1]. In Vivo: CCT251455 demonstrates a good oral pharmacokinetic profile in mouse and rat as well as inhibition of MPS1 activity in vivo following oral administration[1].
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