Simvastatin acid (ammonium)
CAS No. : 139893-43-9
(Synonyms: Tenivastatin (ammonium))
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $180 | In-stock |
| 100mg | $280 | In-stock |
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| Cat. No. : | HY-119695A |
| M.Wt: | 453.61 |
| Formula: | C25H43NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 7 mg/mL (ultrasonic;warming;heat to 60°C) |
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
IC50 & Target:HMG-CoA reductase, Reactive oxygen species[1][2]
In Vitro: Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].
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