Sarolaner
CAS No. : 1398609-39-6
(Synonyms: PF-6450567)
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $460 | In-stock |
| 50mg | $680 | In-stock |
| 100mg | $975 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16730 |
| M.Wt: | 581.36 |
| Formula: | C23H18Cl2F4N2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 300 mg/mL (ultrasonic) |
Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC80 value of 0.3 μg/mL against C. felis and a LC100 value of 0.003 μg/mL against O. turicata[1]. IC50 & Target:LC80: 0.3μg/mL (C. felis)[1]
LC100: 0.003 μg/mL (O. turicata)[1]
IC50: 135 nM (CfRDL-A285), 136 nM (CfRDL-S285)[1] In Vitro: Sarolaner (450 nM-1 mM; 5 min) inhibits CfRDL-A285 and CfRDL-S285 receptors with γ-Aminobutyric acid (GABA)-induced currents[1]. In Vivo: Sarolaner (2.5 mg/kg; p.o. once) shows 100% efficacious against R. sanguineus and D. reticulatus[1]. Sarolaner (1.25- 5 mg/kg; p.o. once) effectively against I. ricinus[1].
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