PF-05105679
CAS No. : 1398583-31-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $182 | In-stock |
| 25mg | $364 | In-stock |
| 50mg | $546 | In-stock |
| 100mg | $819 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-115506 |
| M.Wt: | 428.45 |
| Formula: | C26H21FN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
PF-05105679 is an orally active and selective TRPM8 antagonist with an IC50 of 103 nM. PF-05105679 has the potential for cold-related pain[1].
In Vitro: PF-05105679 demonstrates >100-fold selectivity across a range of different receptors, ion channels, and enzymes including the closely related TRPV1 and TRPA1 channels[1].
TRPM8, also known as the cold and menthol receptor 1 (CMR1), is a member of the melastatin subfamily[1].
In Vivo: PF-05105679 (0.2 mg/kg for iv and 20mg/kg for oral gavage) has a T1/2 of 3.9 hours, a CL of 31 mL/min/kg, and a Vss of 7.4 L/kg for dogs[1].
PF-05105679 (2, 20 mg/kg) has a T1/2 of 3.6 hours, a CL of 19.8 mL/min/kg, and a Vss of 6.2 L/kg for rats[1].
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