Milademetan
CAS No. : 1398568-47-2
(Synonyms: DS-3032)
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $220 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $660 | In-stock |
| 50mg | $1100 | In-stock |
| 100mg | $1850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101266 |
| M.Wt: | 618.53 |
| Formula: | C30H34Cl2FN5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis[1][2].
IC50 & Target: MDM2[1].
In Vitro: Milademetan (DS-3032) can stabilize TP53 and selectively induce CDKNA1, BAX and MDM2 expression in neuroblastoma cells with wild-type TP53[3].
Milademetan (DS-3032b) treatment enhances TP53 target gene expression and induces G1 cell cycle arrest, senescence and apoptosis[3].
Milademetan (DS-3032b, 0-2000 nM) treatment selectively inhibits viability, proliferation and migration of neuroblastoma cells with wildtype TP53 independently of MYCN status[4].
In Vivo: Milademetan (DS-3032b, 50 mg/kg, oral gavage) delays tumor growth and improves survival in mice xenografted with neuroblastoma cells with functional TP53[4].
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