N-Desmethyl Sildenafil
CAS No. : 139755-82-1
(Synonyms: Desmethylsildenafil; UK-103,320)
| Size | Price | Stock |
|---|---|---|
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| 1g | $100 | In-stock |
| 5g | $300 | In-stock |
| 25g | $1050 | In-stock |
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| Cat. No. : | HY-117605 |
| M.Wt: | 460.55 |
| Formula: | C21H28N6O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2].
In Vitro: N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response[1].
The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7[2].
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