Zoptarelin doxorubicin
CAS No. : 139570-93-7
(Synonyms: AEZS-108; AN-152)
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| Cat. No. : | HY-16532 |
| M.Wt: | 1893.01 |
| Formula: | C91H117N19O26 |
| Purity: | >98 % |
| Solubility: | H2O |
Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].
IC50 & Target:Apoptosis, LHRH receptors[1]
In Vitro:Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention[1].
Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin[1].
In Vivo:Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice[1].
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