Mertansine (GMP)
CAS No. : 139504-50-0
(Synonyms: DM1 (GMP); Maytansinoid DM1 (GMP))
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| Cat. No. : | HY-19792G |
| M.Wt: | 738.29 |
| Formula: | C35H48ClN3O10S |
| Purity: | >98 % |
| Solubility: |
Mertansine (GMP) is the GMP-grade version of Mertansine (HY-19792). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC)[1][2].
In Vitro: Mertansine is a strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines[3].
Mertansine (0-1 μg/mL) shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting mitosis when combined with DTX[3].
In Vivo: Mertansine (DM1) has a low maximum-tolerated dose (MTD) of 1 mg/kg[3]
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