TRR469
CAS No. : 1394867-58-3
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| Cat. No. : | HY-112567 |
| M.Wt: | 506.03 |
| Formula: | C28H25ClFN3OS |
| Purity: | >98 % |
| Solubility: |
TRR469 is a positive allosteric modulator of the A1 adenosine receptor (A1AR). TRR469 significantly increases the affinity of 2-chloro N(6)-cyclopentyladenosine (CCPA) for A₁AR, increasing the number of receptors recognized by the agonist radioligand [³H]-CCPA. TRR469 shows significant effects in both anxiety and pain models. TRR469 can be used to study anxiety disorders and pain management[1][2].
In Vitro:TRR469 (10 μM) inhibits the release of excitatory neurotransmitters by enhancing the activation of A₁AR in the spinal cord of mice[1].
In Vivo:TRR469 (0.01-3 mg/kg, i.p., single dose) has a significant analgesic effect on acute inflammatory pain, chemical pain and mechanical abnormal pain in mice[1].
TRR469 (0.3-3 mg/kg, i.p., single dose) demonstrates dose-dependent anti-anxiety effects in all four anxiety models[2].
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