CP-96486
CAS No. : 139401-45-9
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| Cat. No. : | HY-100316 |
| M.Wt: | 502.99 |
| Formula: | C31H23ClN4O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively. IC50 & Target: Ki: 20 nM (LTD4 receptor), 24 nM (PAF receptor)[1] In Vitro: CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki's of 20 and 24 nM respectively[1]. In Vivo: CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50's of 0.27 and 0.26 mg/kg p.o. respectively[1].
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