Selinexor
CAS No. : 1393477-72-9
(Synonyms: KPT-330)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $156 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $700 | In-stock |
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| Cat. No. : | HY-17536 |
| M.Wt: | 443.31 |
| Formula: | C17H11F6N7O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 48 mg/mL |
Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. IC50 & Target:CRM1 In Vitro: As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL cells and elicits rapid apoptotic response. KPT-330 also reduces cell growth in MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3, and DND-41 cell lines, with IC50 values of 34-203 nM [1]. In Vivo: Selinexor (KPT-330) dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells[1]. In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs [2].
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