DBCO-NHS ester 3


CAS No. : 1393350-27-0

1393350-27-0
Price and Availability of CAS No. : 1393350-27-0
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Cat. No. : HY-115545
M.Wt: 416.43
Formula: C24H20N2O5
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 1393350-27-0 :

DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2]. DBCO-NHS ester 3 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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