Thiostrepton
CAS No. : 1393-48-2
| Size | Price | Stock |
|---|---|---|
| 50mg | $50 | In-stock |
| 100mg | $75 | In-stock |
| 500mg | $150 | In-stock |
| 1g | $225 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-B0990 |
| M.Wt: | 1664.89 |
| Formula: | C72H85N19O18S5 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation[1]. In Vitro: Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A[2]. In Vivo: Thiostrepton (i.p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls[3].
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