H2L5186303
CAS No. : 139262-76-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $73 | In-stock |
| 10mg | $117 | In-stock |
| 25mg | $233 | In-stock |
| 50mg | $372 | In-stock |
| 100mg | $594 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107616 |
| M.Wt: | 488.45 |
| Formula: | C26H20N2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
H2L5186303 is a potent and selective LPA2 receptor antagonist with an IC50 of 9 nM. H2L5186303 promotes Apoptosis. H2L5186303 inhibits cell proliferation and motility. H2L5186303 has anti-inflammatory effects[1][2][3].
In Vitro:H2L5186303 (0.3-10 μM, 30 min) inhibits mast cell degranulation[2].
H2L5186303 (10 μM, 2 days) inhibits LPA2 and promotes apoptosis in intestinal epithelial cells (IEC)[3].
H2L5186303 (10 μM) suppresses the cell motile activity of MG63-A12 cells in the presence of Lysophosphatidic acid[4].
In Vivo:H2L5186303 (0-50 mg/kg, given by intraperitoneal injection, single dose) suppresses the levels of eosinophils and lymphocytes in OVA-sensitized mice, and has the trachea inflammation inhibitory effect[2].
H2L5186303 (10 mg/kg, given by intraperitoneal injection, three times every other day, 6 days) inhibits cell proliferation in Lpar5f/f Villin-Cre mice intestinal crypts and promotes apoptosis[3].
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