Verdinexor
CAS No. : 1392136-43-4
(Synonyms: KPT-335)
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $240 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1150 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15970 |
| M.Wt: | 442.32 |
| Formula: | C18H12F6N6O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Verdinexor (KPT-335) is an orally active inhibitor for selective inhibitor of nuclear export (SINE). Verdinexor inhibits the respiratory syncytial virus A2 (RSV A2) replication with an IC50 of 0.96 µM. Verdinexor inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1), inhibiting pro-inflammatory responses. Verdinexor exhibits antitumor effciency[1][2].
In Vitro:Verdinexor (0-10 µM, 72 h) inhibits the proliferation of Jurkat cell and diffuse large B cell lymphoma (DLBCL) cells OCI-Ly3, OCI-Ly10 and CLBL1 with IC50s of 0.3 nM, 2.1 nM, 41.8 nM, and 8.5 nM, respectively[1].
Verdinexor (0-10 µM, 24 h) induces apoptosis in CLBL1 cell and primary canine DLBCL cell[1].
In Vivo:Verdinexor (1-2 mg/kg, po, twice a week for 4 weeks) exhibits antitumor effect against non-Hodgkin lymphoma, but exhibits hepatotoxicity in dogs[1].
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