ZM241385
CAS No. : 139180-30-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $242 | In-stock |
| 50mg | $396 | In-stock |
| 100mg | $550 | In-stock |
| 200mg | $770 | In-stock |
| 1g | $1800 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-19532 |
| M.Wt: | 337.34 |
| Formula: | C16H15N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3]. IC50 & Target: Ki: 1.4 nM (A2AR)[2] In Vitro: ZM241385 (1 μM; 24-48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA and protein levels[1]. In Vivo: ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC[4].
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