Tristin
CAS No. : 139101-67-0
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| 5mg | $680 | In-stock |
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| Cat. No. : | HY-N1117 |
| M.Wt: | 260.29 |
| Formula: | C15H16O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tristin is a PTP1B inhibitor (IC50=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses[1][2][3].
In Vitro: Tristin exhibits broad-spectrum antifungal activity with MIC values ranging from 96.2 to 384.6 μM[2].
Tristin is inactive against HeLa, MCF-7, and A549 cancer cell lines with an IC50 value greater than 10 μM[2].
Tristin inhibits the proliferation of human HL-60 leukemia cells with an IC50 of 29 μM and human THP-1 leukemia cells with an IC50 of 13 μM[3].
Tristin (25 μM) inhibits NO production in LPS-stimulated RAW264.7 macrophages by 27.23%[3].
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