TUG-905
CAS No. : 1390641-90-3
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| Cat. No. : | HY-117787 |
| M.Wt: | 499.59 |
| Formula: | C27H30FNO5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].
IC50 & Target:pEC50: 7.03 (GPR40)[1]
In Vitro:TUG-905 (10 µM; 7, 13 days) increases cell proliferation and DCX mRNA levels of the neuroblast marker[2].
TUG-905 (10 µM; 2, 4, 24 h) increases GPR40, BDNF gene expression in Neuro2a (murine neuroblastoma) cells[2].
In Vivo:TUG-905 (2.0 μL, 1.0 mM; i.c.v.; twice a day for 6 days) reduces body mass and exhibited a trend toward reducing caloric intake[1].
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