L-689560


CAS No. : 139051-78-8

139051-78-8
Price and Availability of CAS No. : 139051-78-8
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1mg $145 In-stock
5mg $380 In-stock
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Cat. No. : HY-101178
M.Wt: 380.23
Formula: C17H15Cl2N3O3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 139051-78-8 :

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2]. In Vitro: L-689560 is a 2-carboxytetrahydroquinoline antagonist[2]. In Vivo: L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1]

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