| Size | Price | Stock |
|---|---|---|
| 1mg | $145 | In-stock |
| 5mg | $380 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-101178 |
| M.Wt: | 380.23 |
| Formula: | C17H15Cl2N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2]. In Vitro: L-689560 is a 2-carboxytetrahydroquinoline antagonist[2]. In Vivo: L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1]
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