KPT-251
CAS No. : 1388841-50-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $330 | In-stock |
| 10mg | $490 | In-stock |
| 25mg | $790 | In-stock |
| 50mg | $1120 | In-stock |
| 100mg | $1800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117996 |
| M.Wt: | 375.23 |
| Formula: | C14H7F6N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity[1][2].
In Vitro: KPT-251 binds in the NES-binding groove, which is located on the central, convex side of the CRM1 ring[1].
KPT-251 (72 h) suppresses melanoma cell proliferation[2].
KPT-251 (1 μM; 0-48 h) modulates levels of p53, pRb, survivin, and ERK phosphorylation[2].
KPT-251 (0.1 and 1 μM; 0-72 h) induces cell-cycle arrest and apoptosis[2].
In Vivo: KPT-251 (75 mg/kg/day; i.g.; three times per week for 5 weeks) effectively suppresses the growth of MV4-11 cells engrafted into NSG mice and provides a significant survival benefit[1].
KPT-251 (50 mg/kg; p.o.; every other day for 21 days) suppresses tumor growth in mice melanoma xenograft models[2].
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