PRE-084
CAS No. : 138847-85-5
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| Cat. No. : | HY-18100 |
| M.Wt: | 317.42 |
| Formula: | C19H27NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PRE-084 is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].
In Vitro: PRE-084 (0.1-100 μM; 24 h) protects cultured cortical neurons against β-amyloid toxicity (maximally neuroprotective at 10 μM) and reduces the levels of proapoptotic protein Bax at 10 μM[1].
In Vivo: PRE-084 (0.25 mg/kg; i.p.; 3 times a week for 8 weeks) displays beneficial effects on motor performance (improves motor neuron survival, ameliorates paw abnormality and grip strength performance) in wobbler mice, and shows neuroprotective effects (increases the levels of BDNF in the gray matter)[2].
PRE-084 (1 mg/kg; i.p.; single) protects the heart by activating the Akt?eNOS pathway in myocardial infarction model[3].
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- HY-18100
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