Umibecestat
CAS No. : 1387560-01-1
(Synonyms: CNP520)
| Size | Price | Stock |
|---|---|---|
| 1mg | $214 | In-stock |
| 5mg | $450 | In-stock |
| 10mg | $650 | In-stock |
| 25mg | $1150 | In-stock |
| 50mg | $1850 | In-stock |
| 100mg | $2950 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-119689 |
| M.Wt: | 513.80 |
| Formula: | C19H15ClF7N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively[1]. Umibecestat can be used for the research of alzheimer's disease.
IC50 & Target: IC50: 11 nM (human BACE-1), 10 nM (mouse BACE-1)[1]
In Vitro: Umibecestat (CNP520) is a potent BACE-1 inhibitor that is selective for BACE-1 over other human pepsin-like aspartic proteases, including BACE-2 and cathepsin D[1].
In Vivo: Umibecestat (CNP520) (1.5-51.3 mg/kg; given by oral gavage; 72 hours) shows a dose-dependent effects on Aβ40 and a long duration of action in both rat brain and CSF[1].
Umibecestat (CNP520) (3.1 mg/kg; oral administration; 7 days) shows a > 75% reduction on Aβ40 and Aβ42 in CSF after dosing and returns slowly to baseline over the next 7 days[1].
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