RO5454948
CAS No. : 1386979-55-0
(Synonyms: Mirk-IN-1; Dyrk1B/A-IN-1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $123 | In-stock |
| 10mg | $192 | In-stock |
| 25mg | $430 | In-stock |
| 50mg | $768 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-12838 |
| M.Wt: | 498.32 |
| Formula: | C23H17Cl2N5O4 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 2 mg/mL (ultrasonic) |
RO5454948 (Compound 9) is the inhibitor for Dyrk1B and Dyrk1A with IC50 of 68 nM and 22 nM. RO5454948 exhibits cytotoxicity in cancer cell SW620 with EC50 of 1.9 μM[1][2]. In Vitro:RO5454948 (0-2.5 μM, 48 h) promotes cancer cells to enter the cell cycle from the quiescent phase, stimulates the generation of ROS, induces DNA damage and apoptosis in cancer cell Panc1[3].
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