SR1555
CAS No. : 1386439-51-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $248 | In-stock |
| 25mg | $540 | In-stock |
| 50mg | $890 | In-stock |
| 100mg | $1470 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-120785 |
| M.Wt: | 460.41 |
| Formula: | C22H22F6N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases[1].
In Vitro: SR1555 (10 μM; 24 h) inhibits Il17a gene expression by greater than 70%in EL4 cells[1].
SR1555 (10 μM; 24 h) inhibits IL-17 protein expression, inhibits TH17 cell differentiation and function, and does not induce cell death during TH17 cell differentiation[1].
SR1555 (10 μM; 24 h) effectively increases the gene expression of Foxp3 while simultaneously suppressing the gene expression of Rorγt[1].
SR1555 increases the frequency of T regulatory cells as evidenced by the almost 2-fold increase in the expression of Foxp3+ T cells in the splenocyte culture[1].
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