N3PT
CAS No. : 13860-66-7
(Synonyms: N3-pyridyl thiamine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $680 | In-stock |
| 100mg | $1080 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16339 |
| M.Wt: | 336.28 |
| Formula: | C13H19Cl2N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 2.86 mg/mL (ultrasonic) |
N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine)[1].
IC50 & Target: transketolase[1]
In Vitro: Transketolase is a key enzyme in pentose phosphate pathway of tumor cells[1].
N3PT (compound 1) shows an average EC50 value of 26 nM against human transketolase in HCT-116 cells[1].
N3PT (1 ppM or 5 ppM) inhibits thiamine-utilizing enzymes activity dramatically without reducing NADPH-containing glucose-6-phosphate dehydrogenase (G6PD) activity[1].
In Vivo: N3PT (compound 1) (100 mg/kg; i.v.; twice a day; 2 weeks) shows inhibitory effect on transketolase activity without significantly anti-tumor activity in HCT-116 tumor-bearing nude mice[1].
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