SPR719
CAS No. : 1384984-18-2
(Synonyms: VXc-486)
| Size | Price | Stock |
|---|---|---|
| 5mg | $480 | In-stock |
| 10mg | $800 | In-stock |
| 25mg | $1550 | In-stock |
| 50mg | $2400 | In-stock |
| 100mg | $3500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12930 |
| M.Wt: | 428.46 |
| Formula: | C21H25FN6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;adjust pH to 2 with HCl) |
SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM)[1][2][3][4].
IC50 & Target:gyrase B[1]
In Vitro:SPR719 inhibits M. tuberculosis replication in macrophages with a MIC range of 0.125-0.25 μg/mL[1][2].
IC50 (μg/ml) of SPR719 for indicated isolate in macrophages[1]
| Compound | H37Ra | CDC1551 |
| SPR719 | 0.012 | 0.115 |