Stacofylline (hydrochloride)
CAS No. : 138472-18-1
(Synonyms: S 9977)
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| Cat. No. : | HY-106412A |
| M.Wt: | 455.98 |
| Formula: | C20H34ClN7O3 |
| Purity: | >98 % |
| Solubility: |
Stacofylline hydrochloride (S 9977), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities[1][2]. In Vitro:Stacofylline hydrochloride potentiates cholinergic transmission by significantly increasing the time constant of decay (Tc) of inhibitory postsynaptic currents (IPSCs)[1]. In Vivo:Stacofylline hydrochloride (0.0312-0.5 mg/kg; p.o.) clearly attenuates the memory deficits induced by the three amnesic treatments after acute treatment in Scopolamine, Diazepam, and electroconvulsive shock (ECS) mouse models,[2].
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