FR 409
CAS No. : 138472-01-2
(Synonyms: NOR 3)
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|---|---|---|
| 1mg | $75 | Get quote |
| 5mg | $187 | Get quote |
| 10mg | $321 | Get quote |
| 50 mg | Get quote | |
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| Cat. No. : | HY-110057 |
| M.Wt: | 215.21 |
| Formula: | C8H13N3O4 |
| Purity: | >98 % |
| Solubility: |
FR 409 (NOR3) is a NO donor and vasodilator. FR 409 increases the diameter of retinal arterioles. FR 409 is toxic to a variety of cells. FR 409 can be used in research on pain and retinopathy[1][2][3][4].
In Vitro:FR 409 (50-100 μM; 17-25 h) is toxic to PC12, NIH-3T3, and MDA-MB-231 cells[2].
In Vivo:FR 409 (2 mM; intrathecal injection; single dose) induces cortical enhancement and mechanical hyperalgesia in male C57BL/6 mice[1].
FR 409 (0.5–10 µg/kg/min; i.v.; single dose) increases the diameter of retinal arterioles and decreases mean arterial pressure in rats in a dose-dependent manner[3].
FR 409 (5 nM/eye; i.v.; single dose) increases the diameter of retinal arterioles in Wistar rats, but does not change mean arterial pressure or heart rate[4].
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