NT157
CAS No. : 1384426-12-3
(Synonyms: Tyrphostin NT157)
| Size | Price | Stock |
|---|---|---|
| 2mg | $90 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $470 | In-stock |
| 50mg | $740 | In-stock |
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| Cat. No. : | HY-100037 |
| M.Wt: | 412.26 |
| Formula: | C16H14BrNO5S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 30 mg/mL (72.77 mM) |
NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway[1][2].
IC50 & Target:IRS-1/2[1]; Stat3[2]
In Vitro: NT157 (0.3-3 μM; 72 hours) shows a strong dose-dependent inhibition of growth in all cell lines tested, and the IC50 s ranges from 0.3 to 0.8 μM[1].
NT157 (1-3 μM; 24 hours) induces cell cycle arrest in MG-63 and U-2OS OS cells[1].
NT157 (1-3 μM; 48 hours) downregulates the Tyr-phosphorylation of IRS-1 in the MG-63 and U-2OS cells[1].
In Vivo: NT157 (50 mg/kg; i.p.; three times per week for 6 weeks) significantly delayed tumor growth in castrated mice bearing LNCaP xenografts [3].
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