A 1070722
CAS No. : 1384424-80-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $79 | In-stock |
| 10mg | $127 | In-stock |
| 50mg | $435 | In-stock |
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| Cat. No. : | HY-107531 |
| M.Wt: | 362.31 |
| Formula: | C17H13F3N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion[1][2].
IC50 & Target:Ki: 0.6 nM (GSK-3)[1]
In Vivo: A 1070722 (10-20 mg/kg, 30 min before cocaine injection or 30 min prior to injection with saline (test day)) decreases spontaneous locomotion, inhibits the expression of conditioned activities but not the acquisition of conditioned activities in Cocaine-paired rats[2].
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