NecroX-5
CAS No. : 1383718-29-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $135 | In-stock |
| 10mg | $196 | In-stock |
| 25mg | $316 | In-stock |
| 50mg | $448 | In-stock |
| 100mg | $585 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-104015 |
| M.Wt: | 645.81 |
| Formula: | C27H39N3O9S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 170 mg/mL (ultrasonic) |
NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity. IC50 & Target: Calcium channel[1] In Vitro: NecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels[1]. NecroX-5 (10 µM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells[2]. In Vivo: NecroX-5 (2.5 mg/kg, everyday other day) inhibits breast cancer cell metastasis in TUBO-P2J tumour-bearing mice[1].
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