Vps34-PIK-III
CAS No. : 1383716-40-2
| Size | Price | Stock |
|---|---|---|
| 2mg | $92 | In-stock |
| 5mg | $172 | In-stock |
| 10mg | $277 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1120 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12794 |
| M.Wt: | 319.36 |
| Formula: | C17H17N7 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL |
Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC50=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs)[1][2][3].
In Vitro:Vps34-PIK-III (1, 5, 10 µM; 24 h) inhibits autophagy and LC3 lipidation in DLD1 cells[1].
Vps34-PIK-III (1, 5, 10 µM; 24 h) leads to an increase in the lipidated and nonlipidated forms of LC3 in DLD1 cells[1].
Vps34-PIK-III (5 µM; 24 h) significantly decreases the expression of stemness genes in HCC cells[2].
Vps34-PIK-III (5 µM; 24 h) suppresses liver CSCs via AMPK activation in Huh7 and MHCC97H cells[2].
In Vivo:Vps34-PIK-III (10 mg/kg; p.o.; single) rapidly absorbed and shows moderate mean systemic clearance (30 mL/min/kg, approximately 33% of hepatic blood flow), with good oral bioavailability (F% = 47)[1].
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