BD-1008 (dihydrobromide)
CAS No. : 138356-09-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $264 | In-stock |
| 50mg | $450 | In-stock |
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| Cat. No. : | HY-100966 |
| M.Wt: | 463.08 |
| Formula: | C15H24Br2Cl2N2 |
| Purity: | >98 % |
| Solubility: | H2O : 12.5 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
BD-1008 dihydrobromide is a nonselective σ receptor antagonist with Kis against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (Ki = 1112 nM) and dopamine transporter (DAT) (Ki > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor[1][2][3].
In Vivo:BD-1008 (10-30 mg/kg, i.p., single dose) dihydrobromide significantly antagonizes the effect of Ditolylguanidine (HY-14218), but has no antagonistic effect on the dopamine effects of PRE-084 (HY-18100)[2].
BD-1008 (1-10 mg/kg, i.p., after multiple doses) dihydrobromide significantly reduces the self-administration of PRE-084 with an ED50 of 3.45 mg/kg in rats[3].
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