Incadronate (disodium)


CAS No. : 138330-18-4

(Synonyms: YM 175; Bisphonal)

138330-18-4
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Cat. No. : HY-B2097
M.Wt: 331.15
Formula: C8H17NNa2O6P2
Purity: >98 %
Solubility:
Introduction of 138330-18-4 :

Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research[1][2][3].

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