TC-2153
CAS No. : 1381769-23-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $255 | In-stock |
| 25mg | $575 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1580 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-124591 |
| M.Wt: | 355.89 |
| Formula: | C7H5ClF3NS5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].
In Vitro:TC-2153 (10 μM; 3 h) decreases the percentage of DOI (HY-103124)-induced c-fos positive neurons in cortical and hippocampal neurons cultured in vitro[1].
In Vivo:Chronic TC-2153 treatment: TC-2153 (20 mg/kg; i.p.; once daily for 7 d) shows antidepressant-like effect without altering locomotor, exploratory activity and anxiety[1].
Acute TC-2153 treatment: TC-2153 (10 mg/kg and 20 mg/kg; p.o.; single dose) inhibits the functional activity of 5-HT2A receptors in vivo in mice[1].
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