Leteprinim
CAS No. : 138117-50-7
(Synonyms: AIT-082 (free acid))
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| Cat. No. : | HY-120251 |
| M.Wt: | 327.29 |
| Formula: | C15H13N5O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species[1][2][3][4].
In Vitro:Leteprinim (5–50 ng/mL, 24 and 48 h) enhances neurotransmitter release, increases secretion of synaptophysin in PC12 cells[2].
In Vivo:Leteprinim (30 or 60 mg/kg, i.p., for 7 days) protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
Leteprinim (60 mg/kg, i.p.) enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4].
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